Department of biomodels

dr. Irena Jonauskienė

Head of department
+370 5 2469219, irena.jonauskiene@imcentras.lt

The Department of Biomodels participates in the program “Molecular and Cellular Immunity Studies in Biological Models at in vitro and in vivo Conditions”, which aims to create individualized therapy technologies based on the investigation of molecular and cellular immunity mechanisms in in vitro and in vivo biomodels. Department follows the theme “Biomodels and their Application in the Study of Immune Processes”. Investigators employ animal models to study normal and various pathological processes and test diagnostic tools and treatment technologies.

Animals bred in our department include transgenic mice, BALB/c, CBA, DBA/2, CC57W and C57Bl/6J line inbred mice, Wistar population rats, guinea pigs and rabbits. The quality of the experiment depends on the genotypes and phenotypes of the animals, thus genetic, clinical, hematological, immunological and biochemical tests are regularly carried out. Using the reciprocal isotransplantation technique, the genotype of the inbred animals is defined, the coefficient of inbreeding approximates is calculated and the line genealogy is followed. Phenotypic evaluation is performed by randomly selecting animals of the same age and determining the ratio of their mass and the weight of separate organs. Besides, hematological and biochemical tests are carried out; the animal health state is always kept under control. The Department of Biomodels not only supplies experimental animals to Lithuanian scientific and educational organizations, but also carries out scientific investigations. The department staff consists of 14 people, 7 of whom are scientific researchers who have a lot of experience working with laboratory animals; 4 employees have finished the International FELASA C category courses.

At the department we perform the following:

  • The studies of the influence of natural, synthetic, microbial and animal origin immunomodulators on the host immune response;
  • Studies of aggressive inflammatory fibroblast interconnections in arthritis models;
  • Experimental studies of carcinogenesis modulators;
  • Phototherapy and photodynamic therapy applications for the management of inflammatory processes. Non-invasive procedure for the treatment of inflammatory synovial tissue is being developed using advanced photonic technologies;
  • Research of new medical devices;
  • New biomodels is being developed for research projects.

 

Achievements:

  • During the last 3 years, the scientific research workers of the Department published 15 scientific articles, 7 of them in IC indexed international journals; participated in different conferences with the reports.
  • Participated in FP7 Project “Immunoglobulin IgY pseudomonas A clinical trial for cystic fibrosis treatment (IMPACTT).
  • Partnership in the project “Intellect LT”.
  • Partnership in the project “Science-Economy-Integration”.
  • Partnership in the Program 2014-2020 European Union Investment in Lithuania.
  • Cooperation in the joint projects with the Lithuanian enterprises of pharmacy and production of biological preparations. Innovation vauchers.

 

Services provided:

  • Supply of laboratory animals: BALB/c, CBA, DBA/2, CC57W, C57Bl/6J line inbred mice, Wistar clone rats and laboratory rabbits for the experiments;
  • Production of monoclonal and polyclonal antibodies;
  • Pre-clinical tests of chemical, biological preparations and medical devices.

Justinas Baleišis

Veterinarian, Junior Researcher, PhD candidate

Romualdas Rudys

Researcher

Rūta Bradūnaitė

Researcher
Dr. Irena Jonauskienė Head of Department, Senior Researcher
Dr. Romualdas Rudys Researcher
Dr. Rūta Bradūnaitė Researcher
Justinas Baleišis Veterinarian, Junior Researcher, PhD candidate
Teresa Normantienė Junior Researcher
Simonas Lengvenis Senior biologist
Ramutė Galiauskienė Senior biologist