(8 5) 262 8636 imc@imcentras.lt Santariškių g. 5, LT-08406, Vilnius Version for the disabled

Department of Immunology

 

Prof. PhD. Vitalij Novickij

Head of Department
+370 5 2469248

Fundamental and applied scientific research, experimental development in immunology, cell culture technologies and immune analysis field, as well as biology doctoral studies, educational activities are implemented in the Department of Immunology of State Research Institute Centre for Innovative Medicine.

The department researchers carries out the long-term scientific research and experimental development programm called “Cellular and molecular immunity researches in biological models in vitro and in vivo”.

The main attention is paid on characterization of immunity state in case of pathology, search of the objective bio markers for diseases diagnostics and immunotherapy effectiveness motoring. The department extends mice, rats monoclonic antibodies collection and it also provides mice, rabbits, rats  and chickens origin polyclonal antibodies production.

Scientific research implemented in this department

7 BP:

  • Immunoglobulin IgY pseudomonas A clinical trial for cystic fibrosis treatment (IMPACTT), (2010-2014)

Lithuania-Latvia-China (Taiwan) collaboration program:

  • Establishing of the framework to track molecular epidemiology of Parvoviruses and to correlate sequence variability with different clinical manifestations (2012-2014)

Nacional scientific program projects: 

  • Precision next-generation exon sequencing technology for healthy aging in patients with a predisposition to breast and ovarian cancer (2015-2018)
  • Targeted new sequence for genetic predisposition to breast, ovarian and colon cancer (2012-2014)
  • Biocontrol of microorganisms activating under microgravity conditions and causing skin infections using electro-magnetoporation (2016-2018)

Scientific groups projects:

  • Influence of electrochemotherapy and its combination with dendritic cell vaccination on the elimination of fungal tumors and the formation of the immune response (2019-2022)
  • Non – invasive detection of immunological markers in amniotic fluid during preterm labor (2019-2022)
  • Research of persistent infection and its association with autoimmune epithelium (2014-2016)

Partners

While doing scientific researches immunology department collaborates with Lithuanian and foreign countries science institutions and business companies. The main immunology department partners are: 

-Vilnius University

  • National Cancer Institute
  • Vilnius Gediminas Technical University  
  • Karolinska Institute( Sweden)
  • August Kirchenstein microbiology and virology Institute (Latvia ) 
  • Business companies as Thermo Fisher Scientific Baltics, BIOTECHPHARMA, Biocenter, Innovative Pharma Baltics and others.

10 doctorates are studying in this department.

Contacts

The email addresses of IMC employees are made as shown below (Lithuanian diacritics are not used):
First letter of the name.surname@imcentras.lt
If the employee has two names, the first letter of his/her first name is used in the email address.

Chief Researcher
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Senior Researcher
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PhD Auksė Zinkevičienė

Senior Researcher

Education

 PhD Biomedical Sciences
The topic and institution of the defended work

“Yeast in atopic dermatitis etiology” Vilnius University
Employment CIM, Senior Researcher
Publications  Timegap: 2012 – 2018

  1. Novickij, V, Zinkevičienė, A, Valiulis, J, Švedienė, J, Paškevičius, A, Lastauskienė, E, Markovskaja, S, Novickij, J, Girkontaitė, I. Different permeabilization patterns of splenocytes and thymocytes to combination of pulsed electric and magnetic field treatments // Bioelectrochemistry. 2018, Vol. 122, p. 183-190. IF: 3.789
  2. Novickij, V, Švedienė, J, Paškevičius, A, Markovskaja, S, Lastauskienė, E, Zinkevičienė, A, Girkontaitė, I, Novickij, J. Induction of different sensitization patterns of MRSA to antibiotics using electroporation // Molecules. 2018, vol. 23, iss. 7, art. no. 1799, p. 1-10. IF: 3.098
  3. Lastauskienė, E, Novickij, V, Zinkevičienė, A, Girkontaitė, I, Paškevičius, A, Švedienė, J, Markovskaja, S, Novickij J. Application of pulsed electric fields for the elimination of highly drug-resistant Candida grown under modelled microgravity conditions // International Journal of Astrobiology. 2018. https://doi.org/10.1017/S1473550418000332. IF: 1.921
  4. Novickij, V, Lastauskienė, E, Švedienė, J, Grainys, A, Staigvila, G, Paškevičius, A, Girkontaitė, I, Zinkevičienė, A, Markovskaja, S, Novickij, J. Membrane permeabilization of pathogenic yeast in alternating sub-microsecond electromagnetic fields in combination with conventional electroporation // Journal of membrane biology. 2018, Vol. 251, iss. 2, p. 189-195. IF: 1.638
  5. Novickij, V, Zinkevičienė, A, Perminaitė, E, Čėsna, R, Lastauskienė, E, Paškevičius, A, Švedienė, J, Markovskaja, S, Novickij, J, Girkontaitė, I. Non-invasive nanosecond electroporation for biocontrol of surface infections: an in vivo study // Scientific reports. 2018, vol. 8, art. no. 14516, p. 1-9. IF: 4.122
  6. Novickij, V, Švedienė, J, Paškevičius, A, Markovskaja, S, Girkontaitė, I, Zinkevičienė, A, Lastauskienė, E, Novickij, J. Pulsed electric field-assisted sensitization of multidrug-resistant Candida albicans to antifungal drugs // Future microbiology. 2018, Vol. 13, iss. 5, p. 535-546. IF: 3.190
  7. Novickij, V, Girkontaitė, I, Zinkevičienė, A, Švedienė, J, Lastauskienė, E, Paškevičius, A, Markovskaja, S, Novickij, J. Reversible permeabilization of cancer cells by high sub-microsecond magnetic field // IEEE transactions on magnetics. 2017, Vol. 53, iss. 11, p. 1-4. IF: 1.467
  8. Naciūtė, G. Mačiūnaitė, D. Mieliauskaitė, R. Rugienė, Zinkevičienė, M. Mauricas, M. Murovska,I. Girkontaitė. Increased numbers of CD4+CD25+ and CD8+CD25+ T-cells in peripheral blood of patients with rheumatoid arthritis with parvovirus B19 infection. In vivo. 2017. 31(2): 181-186.
  9. Novickij,I. Girkontaitė, A. Grainys, A. Zinkevičienė, E. Lastauskienė, J. Švedienė, A. Paškevičius, S. Markovskaja, J. Novickij. Measurement of transient permeability of Sp2/0 myeloma cells:flow cytometric study. Measurement Science Review. 2016. 16(6): 300–304.
  10. Zinkevičienė, D. Kainov,I. Girkontaitė,  E. Lastauskienė, V. Kvedarienė, Y. Fu, S. Anders, V. Velagapudi. Activation of tryptophan and phenylalanine catabolism in the remission phase of allergic contact dermatitis: a pilot study. International Archives of Allergy and Immunology. 2016. 170(4): 262-268.
  11. Zinkevičienė, D. Kainov, E. Lastauskienė, V. Kvedarienė, D. Bychkov, M. Byrne,I. Girkontaitė. Serum Biomarkers of allergic contact dermatitis: a pilot study. International Archives of Allergy and Immunology. 2015. 168(3): 161-164.
  12. Novickij, A. Grainys, E. Lastauskienė, R. Kananavičiūtė, D. Pamedytytė,A. Zinkevičienė, L. Kalėdienė, J. Novickij, A. Paškevičius, J. Švedienė. Growth inhibition and membrane permeabilization of Candida lusitaniae using varied pulse shape electroporation. BioMed Research International. 2015. Article ID 457896.
  13. Šaulienė I., Greičiuvienė J., Šukienė L., Juškevičiūtė N., Benner Ch., Zinkevičienė A., Ripatti S., Donner K., Kainov D. Genetic loci associated with allergic sensitization in Lithuanians. PLOS ONE. 2015; 10(7); e0134188. doi:10.1371/journal.pone.0134188.
  14. Lastauskienė E., Čeputytė J., Girkontaitė I., Zinkevičienė A. Phenotypic switching of Candida quilliermondii is associated with pseudohyphae formation and antifungal resistance. Mycopathologia. 2015; 179: 205-211.
  15. Lastauskienė E., Zinkevičienė A., Girkontaitė I., Kaunietis A., Kvedarienė V. Formic acid and acetic acid induce a programmed cell death in pathogenic Candida Curr Microbiol. 2014; 69(3): 303-310.
  16. Lastauskienė E., Zinkevičienė A., Čitavičius D. 2013 Ras/PKA signal transduction pathway participates in regulation of yeast Saccharomyces cerevisiae cell apoptosis in acid environment. Appl. Biochem. 2014; 61 (1): 3-10.
  17. Zinkeviciene A, Girkontaite I, Citavicius D. Specific immunoglobulin E antibodies to saprophytic yeasts in sera of atopic patients allergic to house dust mites. J Investig Allergol Clin Immunol. 2012;22(6):412-8.
  18. Zinkeviciene A., Norkunas V., Citavicius D. Atypical non-lipid-dependent strains of Malassezia furfur, Cent. Eur. J. Biol. 2012; 7, 241-249.
Projects “Electro-magnetoporation mediated biocontrol of the microgravity affected and skin infections causative microorganisms”, Research Council of Lithuania, Towards future technologies program
Areas of interest, directions of cooperation

Biomarkers

Senior Researcher
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PhD Dainius Characiejus

Senior Researcher
Education Vilnius University
The topic and institution of the defended work „Local reactions of macrophages during development and growth of malignant tumours“ (Saint Petersburg, Russia, 1986)
Employment Senior researcher
Publications 1. Zaleskis, Gintaras; Garberytė, Sima; Pavliukevičienė, Božena; Valinčius, Gintaras; Characiejus, Dainius; Mauricas, Mykolas; Krasko, Jan Aleksander; Žilionytė, Karolina; Žvirblė, Margarita; Pašukonienė, Vita. Doxorubicin uptake in ascitic lymphoma model: Resistance or curability is governed by tumor cell density and prolonged drug retention // Journal of Cancer : Ivyspring International Publisher. ISSN 1837-9664. eISSN 1837-9664. 2020, 11, 22, p. 6497-6506. DOI: 10.7150/jca.46066.
2. Tulytė, Skaistė; Tamulytė, Ieva; Diglys, Domantas; Characiejus, Dainius; Matuzevičienė, Rėda; Janiulionienė, Aušra; Žvirblis, T.; Šileikis, Audrius. Chemotherapy related changes of peripheral blood lymphocytes in advanced and metastatic PDAC // Annals of oncology. Amsterdam : Elsevier. 2020;31(4):S952. DOI: 10.1016/j.annonc.2020.08.2042.
3. Tulytė, Skaistė; Šileikis, Audrius; Tamulytė, Ieva; Ranceva, Anastasija; Characiejus, Dainius; Matuzevičienė, Rėda; Janiulionienė, Aušra; Žvirblis, Tadas. Circulating T cell subsets differ in PDAC patients at initial diagnosis and after two months of treatment: a single institution prospective study // Annals of oncology. Oxford : Oxford University Press. ISSN 0923-7534. eISSN 1569-8041. 2019, vol. 30, suppl. 4, art. no. P-137, p. 37. DOI: 10.1093/annonc/mdz155.136.
4. Chmieliauskas, Sigitas; Laima, Sigitas; Fomin, Dmitrij; Jurolaic, Eleonora; Jasulaitis, Algimantas; Stasiūnienė, Jurgita; Characiejus, Dainius; Utkus, Algirdas. Homicide victims and mechanisms in Lithuania from 2004 to 2016. // Journal of forensic and legal medicine. Oxford : Elsevier science. 2019;65:27-31. DOI: 10.1016/j.jflm.2019.04.010.
5. Novickij, Vitalij; Čėsna, Robertas; Perminaitė, Emilija; Zinkevičienė, Auksė; Characiejus, Dainius; Novickij, Jurij; Šatkauskas, Saulius; Ruzgys, Paulius; Girkontaitė, Irutė. Antitumor response and immunomodulatory effects of sub-microsecond irreversible electroporation and its combination with calcium electroporation // Cancers. Basel : MDPI AG. ISSN 2072-6694. eISSN 2072-6694. 2019;11(11)1-18. DOI: 10.3390/cancers11111763.
6. Juršėnaitė, Jurgita; Girkontaitė, Irutė; Šiaurys, Almantas; Mauricas, Mykolas; Characiejus, Dainius. Intratumoral accumulation and clonal expansion may not be decisive for rejection of allogeneic tumors by CD8+ T-lymphocytes // Anticancer research. Athens : International Institute of Anticancer Research. ISSN 0250-7005. eISSN 1791-7530. 2018, vol. 38, no 8, p. 4481-4484. DOI: 10.21873/anticanres.12751.
7. Rutkauskaitė, Vilma; Ragelienė, Lina; Matuzevičienė, Rėda; Sinkevič, Katažina; Mauricas, Mykolas; Characiejus, Dainius. Reduction in proportion of senescent CD8+ T lymphocytes during chemotherapy of children with acute lymphoblastic leukemia // Anticancer research. Athens : International Institute of Anticancer Research. ISSN 0250-7005. eISSN 1791-7530. 2016, Vol. 36, Iss. 11, p. 6195-6199. DOI: 10.21873/anticanres.11213.
8. Juršėnaitė, Jurgita; Girkontaitė, Irutė; Mauricas, Mykolas; Eidukevičius, Rimantas; Šiaurys, Almantas; Characiejus, Dainius. Bioluminescence imaging of adoptively transferred lymphocytes during allogeneic tumor rejection // Anticancer research. Athens : International Institute of Anticancer Research. ISSN 0250-7005. 2015, Vol. 35, no 12, p. 6573-6576.
9. Sūdžius, Gintaras; Mieliauskaitė, Diana; Šiaurys, Almantas; Vilienė, Rita; Butrimienė, Irena; Characiejus, Dainius; Dumalakienė, Irena. Distribution of peripheral lymphocyte populations in primary Sjögren’s syndrome patients // Journal of immunology research. New York : Hindawi Publishing Corporation. 2015;2015:1-10. DOI: 10.1155/2015/854706.
10. Sūdžius, Gintaras; Mieliauskaitė, Diana; Šiaurys, Almantas; Vilienė, Rita; Butrimienė, Irena; Characiejus, Dainius; Dumalakienė, Irena. Could the complement component C4 or its fragment C4d be a marker of the more severe conditions in patients with primary Sjögren’s syndrome? // Rheumatology international. Heidelberg : Springer. ISSN 0172-8172. 2014, vol. 34, iss. 2, p. 235-241.
11. Characiejus, Dainius; Juršėnaitė, Jurgita. In vivo imaging of antitumor lymphocytes // Anticancer research. Kapandriti : International Institute of Anticancer Research. ISSN 0250-7005. 2014, vol. 34, no. 10, p. 5859.
12. en Otter, Willem; van Moorselaar, R. Jeroen; Jacobs, John J.L.; Ter Haar, Ronald; Koten, Jan W.; Dobrowolski, Zygmunt; Lipczynski, Waclaw; Pašukonienė, Vita; Characiejus, Dainius; Jankevičius, Feliksas; Eidukevičius, Rimantas; de Reijke, Theo M. Role of marker lesion when applying intravesical instillations of IL-2 for non-muscle-invasive bladder cancer comparison of the therapeutic effects in two pilot studies // Anticancer research. Kapandriti : International Institute of Anticancer Research. ISSN 0250-7005. 2013;33(5):2099-2105.
13. Strioga, Marius; Pašukonienė, Vita; Dobrovolskienė, Neringa; Petraitis, Tadas; Kazlauskaitė, Nijolė; Darinskas, Adas; Jokubauskienė, Lina; Characiejus, Dainius. Quantitative changes within the peripheral blood CD8highCD57+ T-cell subpopulation of patients with advanced renal cell carcinoma // Acta medica Lituanica. Vilnius : Lietuvos mokslų akademija. ISSN 1392-0138. 2013, vol. 20, nr. 4, p. 147-159. DOI: 10.6001/actamedica.v20i4.2812.
14. Juršėnaitė, Jurgita; Girkontaitė, Irutė; Mauricas, Mykolas; Eidukevičius, Rimantas; Characiejus, Dainius. Expanded effector memory T-lymphocytes in DBA/2 mice do not inhibit the growth of SL2 tumours // In vivo. Athens : International Institute of Anticancer Research. ISSN 0258-851X. 2012, Vol. 26, no. 4, p. 553-558.
15. Fox, Bernard A.; Schendel, Dolores J.; Butterfield, Lisa H.; Characiejus, Dainius. Defining the Critical Hurdles in Cancer Immunotherapy // Journal of translational medicine. London : BioMed Central Ltd. ISSN 1479-5876. 2011, Vol. 9, Art. No. 214. DOI: 10.1186/1479-5876-9-214.
Areas of interest, directions of cooperation

Cancer immunology

Researcher
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PhD Aušra Nemeikaitė – Čenienė

Researcher
Education Vilnius University, Faculty of Natural Sciences, 1986, biology.
The topic and institution of the defended work „Characterization of bovine leukemia virus-producing cellcultures“, Institute of Immunology, 1995.
Employment Researcher, Department of Immunology
Publications 1. A. Nemeikaitė-Čėnienė, J. Šarlauskas, L. Misevičienė, A. Marozienė, V. Jonušienė, M. Lesanavičius, N. Čėnas (2020). Aerobic Cytotoxicity of Aromatic N-Oxides: The Role of NAD(P)H:Quinone Oxidoreductase  (NQO1). International Journal of Molecular Sciences 21:8754.
2. A. Nemeikaitė-Čėnienė, J. Šarlauskas, V. Jonušienė, A. Marozienė, L. Misevičienė, A.V. Yantsevich, N. Čėnas (2019). Kinetics of Flavoenzyme-Catalyzed Reduction of Tirapazamine Derivatives: Implications for Their Prooxidant Cytotoxicity. International Journal of  Molecular Sciences 20:4602.
3. J. Šarlauskas, A. Nemeikaitė-Čėnienė, A. Marozienė, L. Misevičienė, M. Lesanavičius, N. Čėnas (2018). Enzymatic single-electron reduction and aerobic cytotoxicity of tirapazamine and its 1-oxide and nor-oxide metabolites. Chemija 29: 273-280.
4.  A. Javmen, A. Nemeikaitė-Čėnienė, S. Grigiškis, J. Lysovienė, I.     Jonauskienė, A. Šiaurys, M. Mauricas (2017). The effect of Saccharomyces cerevisiae β-glucan on proliferation, phagocytosis and cytokine production of murine macrophages and dendritic cells.      Biologia (ISSN: 0006-3088): 72(5): 561—568.
5. M. Ger, A. Kaupinis, A. Nemeikaitė-Cėnienė, J. Šarlauskas, J. Cicėnas, N. Čėnas, M. Valius (2016). Quantitative proteomic analysis of anticancer drug RH1 resistance in liver carcinoma. Biochimica et Biophysica Acta: Proteins and Proteomics 1864: 219-232.
6. A. Javmen, A. Nemeikaitė-Čėnienė, M. Bratchikov, S. Grigiškis,     F. Grigas, I. Jonauskienė, D. Zabulytė, M. Mauricas (2015). β-Glucan from Saccharomyces cerevisiae Induces IFN-γ Production In Vivo in  BALB/c Mice. In Vivo 29: 359-363.7. A. Javmen, A. Nemeikaitė-Čėnienė, S. Grigiškis, I. Jonauskienė, M. Rudenkov, D. Kačianauskas, M. Mauricas (2015). S. cerevisiae β-glucan reduced viability of mouse hepatoma cells in vitro. Turkish Journal of  Biology 39: 562-566.
8. A. Nemeikaitė-Čėnienė, R. Jarašienė, H. Nivinskas, J. Šarlauskas, N. Čėnas (2015).Cytotoxicity of anticancer aziridinyl-benzoquinones in  murine hepatoma MH22a cells: the properties of RH1-resistant subline. Chemija. 26(1): 46-50.
9. V. Miliukienė, A. Nemeikaitė-Čėnienė, N. Čėnas (2014). Prooxidant cytotoxicity of polyphenolic compounds in primary mice splenocytes: role of redox potential and lipophilicity. Chemija. 25(4), 218-223.
10. J. Šarlauskas, A. Nemeikaitė-Čėnienė, L. Misevičienė, K. Krištopaitis, Ž. Anusevičius, N. Čėnas (2013). Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX). Acta Biochim Pol. 60(2): 227-231.
11.  A. Marozienė, A. Nemeikaitė-Čėnienė, R. Vidziunaitė, N. Čėnas   (2012). Correlation between mammalian cell cytotoxicity of flavonoids and the redox potential of phenoxyl radical/phenol couple. Acta Biochim Pol. 59(2), 299-305.
12. Skyrius monografijoje: N. Čėnas, A. Nemeikaitė-Čėnienė, J. Šarlauskas, Ž. Anusevičius, H. Nivinskas, L. Misevičienė, A. Marozienė. Mechanisms of mammalian cell cytotoxicity of expplosives. In: Ecotoxicology of Explosives, G.I. Sunahara, G. Lotufo, R.G. Kuperman, J. Hawari, Eds., CRC Press, Boca Raton, New York, 2009, 211-226.
Projects “Redox chemistry, biochemistry and cytotoxicity of aromatic nitrocompounds and N-oxides: new insights”, No. 09.3.3-LMT-K-712-01-0058, 2018-2022 (Universal Dotation, team member).“Molecular mechanisms of toxicity and antitumour activity of quinones and polyphenols: enzymatic redox reactions, cytotoxicity, signal transduction and proteomics”, No. VP1-3.1-ŠMM-07-K01-103 (Universal Dotation, team member)
Areas of interest, directions of cooperation Cell cultures, methods of cultivation of cell cultures; The  in vitro studies of the mechanisms of cytotoxicity, genetoxicity of quinoidal and nitroaromatic drugs and environmental contaminants and polyphenolic antioxidants, free radical processes and oxidative stress. The in vitro studies of action mechanisms of natural and synthetic immunomodulators.

Junior Researcher
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 PhD Ieva Narkevičiūtė

Junior Researcher

Education

 Centre for Innovative Medicine, Department of Immunology; Vilnius; PhD Biological sciences | 2020
Vilnius Gediminas technical university; Vilnius; MSc of biotechnology | 2015
Vilnius Gediminas technical university;  Vilnius; BSc of bioengineering | 2013

The topic and institution of the defended work

 “Comparative Studies On The Expression Of Type I And II Interferons And Their Producing Cells In Autoimmune Rheumatic Processes”
Dissertation was prepared at State Research Institute Centre for Innovative Medicine in 2015–2019. The right of doctoral studies was granted to Vytautas Magnus University jointly with Nature Research Centre and Centre for Innovative Medicine, on 17 July, 2017, by the decision No. V–574 of the Government of the Republic of Lithuania.
Employment 2015 October – now  
Centre for Innovative medicine, Department of immunology           
Junior scientist
 2015 February – 2015 September
Centre for Innovative medicine, Department of immunology
Engineer-microbiologist
 2010 October – 2014 October
Vilnius Gediminas technical university, Faculty of environmental engineering
Laboratory technician
Publications
  1. Bartkevičienė, I. Pilypienė, D. Serapinas, B. Vaigauskaitė, R. A. Vankevičiūtė, A. Bartkevičiūtė, I. Narkevičiūtė, I. Dumalakienė, “Umbilical Blood Levels of IL-6 and TNF-a as Predictors of the Central Nervous System Damage and Retinopathy ir Preterm Infants”, Am J Perinatol. (2020). Doi: 10.1055/s-0040-1701508.
  2. Zinkevičienė, I. Dumalakienė, D. Mieliauskaitė, R. Vilienė, I. Narkevičiūtė, I. Girkontaitė, “sICAM-1 as potential additional parameter in the discrimination of the Sjögren syndrome and non-autoimmune sicca syndrome: a pilot study”, Clin. Rheumatol. (2019). doi:10.1007/s10067-019-04621-2.
  3. Mackiewicz, J. Mażul, I. Narkevičiūtė, I. Dumalakienė, I. Butrimienė, R. Vilienė, I. Stankevičienė, D. Mieliauskaitė, “Sjögren’s Syndrome: Concerted Triggering of Sicca Conditions”, J. Immunol. Res. 2019 (2019) 1–11. doi:10.1155/2019/2075803.
  4. Narkeviciute, D. Mieliauskaite, Z. Mackiewicz, I. Butrimiene, R. Viliene, I. Dumalakiene, “Distribution of Myeloid-Derived Suppressor Cells in Rheumatoid Arthritis and Sjögren’s Syndrome”, Arch. Rheumatol. 34 (2019) 53–61. doi:10.5606/ArchRheumatol.2019.6813.
  5. Narkeviciute, G. Sudzius, D. Mieliauskaite, Z. Mackiewicz, I. Butrimiene, R. Viliene, I. Dumalakiene, “Are cytotoxic effector cells changes in peripheral blood of patients with Sjögren’s syndrome related to persistent virus infection: Suggestions and conundrums”, Cell. Immunol. 310 (2016) 123–30. doi:10.1016/j.cellimm.2016.08.013.
Projects MIP-14258 „Investigation of persistent infection and its association with autoimmune epithelitis”
Funded by Reaserch council of Lithuania; Project duration: 3 years; Scientific leader: habil. dr. Zygmunt Mackevič;
Areas of interest, directions of cooperation

Immunology, autoimmune diseases, ATMP

Junior Researcher
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Rita Vilienė

Junior Researcher

Education

 State Education Institute of Vilnius, biology speciality master
Employment State Research Institute Center for Innovative Medicine, Junior scientist
Publications
  1. Vyšniauskis, I.Dumalakienė, A.Šiaurys, R.Vilienė, I.Jonauskienė, J.Šiugždaitė. Isolation and comparison of chicken mycoplasma field isolates. Biologija, 2000, 2,  221 -223.
  2. Reda Rimavičiūtė, Irena Dumalakienė, Rita Vilienė, Rita Meškienė, Rolandas Meškys. Construction of DNA vector system for Mycoplasma gallinarum.Romanian Biotechnology Letters.Vol.17, No.4, 2012, 7533 -7539.
  3. Gintaras Sudzius, Diana Mieliauskiatė, Almantas Siaurys, Rita Vilienė, Irena Butrimienė, Dainius Characiejus & Irena Dumalakienė. Could the complement component C4 or its fragment C4 be a marker of the more servere conditions in patients with primary Sjogren’s syndrome? Reumatol Int (2014) 34:235-241. DOI 10.1007/s00296-013-2885-y.
  4. Gintaras Sudzius, Diana Mieliauskaitė, Almantas Siaurys, Rita Vilienė, Irena Butrimienė, Dainius Characiejus and Irena Dumalakienė. Distribution of peripheral lymphocyte populations in Primary Sjongren’s sindrome patients.Immunology Research, vol.2015, Article ID 854706, 10 pages, 2015. doi: 10.1155/2015/854706.
  5. Narkevičiūtė I., Sudzius G., Mieliauskaitė D., Mackewicz Z., Butrimienė I., Vilienė R., Dumalakienė I. Are cytotoxic effector cells changes in peripheral blood of patients with Sjongren’s sindrome related to persistent virus infection: Suggestions and conundrums, Cell. Immunol., 2016, 310, 123-130.http://dx.doi.org/10.1016/j.cellimm.2016.08.13.4
  6. Zygmunt Mackiewicz, Justyna Mazul, Ieva Narkeviciutė, Irena Dumalakienė, Irena Butrimienė, Rita Vilienė, Indre Stankeviciene, Diana Mieliauskaitė. Sjogren’s sindrome: concerted triggering of sicca conditions. 2018, Journal of Immunology Research. Journal of Immunology Research Volume 2019, Article ID 2075803, 11 pages https://doi.org/10.1155/2019/2075803.
  7. Ieva Narkeviciute, Diana Mieliauskaitė, Zygmunt Mackiewicz, Irena Butrimienė, Rita Vilienė, Irena Dumalakienė. Distribution of Myeloid-Derived Suppressor Cells in Rheumatoid Arthritis and Sjogren’s Syndrome. Arch Rheumatol 2019;34(x):1-9. doi:10.5606/ArchRheumatol.2019.6813.
  8. Zinkevičienė, I.Dumalakienė, D. Mieliauskaitė, R.Vilienė, I. Narkevičiūtė, I. Girkontaitė s/CAM-1 as potential additional parametre in the discrimination of the “Sjongren sindrome and non-autoimmune sicca syndrome : a pilot study”,Rheumatol. (2019). doi: 10.1007/s10067-019-04621-2.
  9. Joana Korabliovienė, Mykolas Mauricas, Irena Dumalakienė, Saulius Čeplinskas, Rita Vilienė, Justinas Baleišis, Gintauatas Vyšniauskis, Joana Chorostowska-Wynimko, Pavel Korabliov, Ginreta Magelinskienė, Arūnas Valiulis. BCG masking phenomena might depend on the species of Mycobacterium. Acta Microbiologica et Immunologica Hungarica. 2021.doi:10.1556/030.2021.01324.
  10. Greta Balciunienė, Violeta Gulbinienė, Irena Dumalakienė, Rita Vilienė, Daiva Bartkevičienė, Ingrida Pilypienė, Diana Ramasauskaitė. Diagnostic markers for chorioamnionitis: IL-6, THF-α and MMP-8in vaginally obtained amniotic fluid. „American Journal of Obstetrics and Gynecology“.https:/doi.org/10.3390/jcm10051136. 2021.
Projects 2001 -2003 – „Vaikų kvėpavimo takų patogeninių mikoplazmų ir jų poveikio imuninei būklei tyrimas“. Reg Nr. 26041; Agreement no. K-040.
2004 „Imuninis atsakas į mikoplazmas ir chlamidijas vaikų organizme“, Reg. No. T-04215, Agreenent No. T-28/04.
2006 „Melatonino apykaita epilepsija sergančių vaikų organizme ir jo įtaka imuninei sistemai“. No. T -39/06, reg. No. T – 06131.
„Uždegimo žymenų reikšmė, prognozuojant ankstyvus ir vėlyvus neišnešioto naujagimio sveikatos sutrikimus“, 2008, Agreement No. T – 101/08. P
„Mažųjų genomų analizė ir metagenominių metodų panaudojimas naujų biokatalizatorių atrankai. MetaGENAS“, 2008 – 2010. Agreement No. 18(2008(2008(2). 
„Interleukinų-27, 35 ir T helperių 1, 2, 17 vaidmuo autoimuninio epitelito prognozėje“. 
„Autoimuninėmis ligomis sergančių ligonių T limfocitų populiacijų reikšmė ligos eigai“, 2010 08 – 2011.12.
 „Persistuojančios infekcijos ir jos ryšio su autoimuniniu epitelitu tyrimas“, 2014 – 2016.
„Neinvazinis imunologinių žymenų nustatymas vaisiaus vandenyse priešlaikinio gimdymo metu‘, VU-NI No. (1.79) SU – 1795. 2019 –2022.
Areas of interest, directions of cooperation Molecular and cellular immunity research on biological models in vitro and in vivo.

PhD Candidate
×

Evelina Gorbikova

PhD Candidate

Education

 Master of Clinical Biology
Employment PhD student
Areas of interest, directions of cooperation Allergology, clinical microbiology and infectious diseases

PhD Candidate
×

Robertas Čėsna

PhD Candidate

Education

 Master degree
The topic and institution of the defended work „Laser-induced choroidal neovascularization model in Dutch Belted rabbits“
Employment Doctoral student
Publications
  1. Vitalij Novickij et al.; „Non-invasive nanosecond electroporation for biocontrol of surface infections: an in vivo study“, Scientific Reports volume 8, Article number: 14516 (2018).
  2. Vitalij Novickij et al.; „Antitumor Response and Immunomodulatory Effects of Sub-Microsecond Irreversible Electroporation and Its Combination with Calcium Electroporation“, Cancers volume 11(11), Article number:1763 (2019).
  3. Robertas Čėsna et al.; „Comparative efficacy of bevacizumab and aflibercept in the rabbit DL-AAA model of chronic retinal neovascularization“, Investigative Ophthalmology & Visual Science volume 61, Article number:5391 (2020).

Projects

 „Pre-clinical study of age-related macular degeneration: miR-17-5p as VEGF modulator“
Areas of interest, directions of cooperation UAB „Experimentica“

Chief Researcher
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Prof. A. Ramanavičienė

Chief Researcher
Education Higher education at Vilnius University.
Doctor of Biomedical Sciences, Biology.
The topic and institution of the defended work Doctoral thesis „Influence of anthropogenic factors on the immune status of cattle and new methods for its evaluation“. Vilnius University and Institute of Immunology in 2002. Biomedical sciences, biology.
Habilitation procedure „Aspects of analysis and application of polypyrrole and materials used for its modification”. Vilnius University and Institute of Immunology in 2008. Physical sciences, chemistry.
Employment Vilnius University, Faculty of Chemistry and Geosciences, Institute of Chemistry. Professor.
State Research Institute Centre for Innovative Medicine, Department of Immunology. Senior researcher.
Publications 197 scientific papers in Clarivate Analytics Web of Science referred journals and books (h index 42), 4 chapters in the books, and over 100 conference abstracts and proceedings.
More information:
https://scholar.google.lt/citations?user=wcPtthkAAAAJ&hl=en
Projects Project under the Programme „Attracting Foreign Researchers for Research Implementation“ (SMART) „Development of a nanobiosensor: a diagnostic biomarkers for personalization of osteoarthritis therapy“ 2019-2021, participant of the project.
Areas of interest, directions of cooperation Development of biosensors (enzymatic and immunosensors) for bioanalysis and biomedicine using electrochemical, optical and piezoelectric signal transducers; synthesis of metallic and polymeric nano- and micro-particles, characterization, modification by protein and application in analytical systems; site-directed immobilization of antibodies using different methods; study of proteins interaction; synthesis of p-p conjugated polymers and application in analytical systems.

Chief Researcher
×

Prof. A. Ramanavičienė

Chief Researcher
Education Higher education at Vilnius University.
Doctor of Biomedical Sciences, Biology.
The topic and institution of the defended work Doctoral thesis „Influence of anthropogenic factors on the immune status of cattle and new methods for its evaluation“. Vilnius University and Institute of Immunology in 2002. Biomedical sciences, biology.
Habilitation procedure „Aspects of analysis and application of polypyrrole and materials used for its modification”. Vilnius University and Institute of Immunology in 2008. Physical sciences, chemistry.
Employment Vilnius University, Faculty of Chemistry and Geosciences, Institute of Chemistry. Professor.
State Research Institute Centre for Innovative Medicine, Department of Immunology. Senior researcher.
Publications 197 scientific papers in Clarivate Analytics Web of Science referred journals and books (h index 42), 4 chapters in the books, and over 100 conference abstracts and proceedings.
More information:
https://scholar.google.lt/citations?user=wcPtthkAAAAJ&hl=en
Projects Project under the Programme „Attracting Foreign Researchers for Research Implementation“ (SMART) „Development of a nanobiosensor: a diagnostic biomarkers for personalization of osteoarthritis therapy“ 2019-2021, participant of the project.
Areas of interest, directions of cooperation Development of biosensors (enzymatic and immunosensors) for bioanalysis and biomedicine using electrochemical, optical and piezoelectric signal transducers; synthesis of metallic and polymeric nano- and micro-particles, characterization, modification by protein and application in analytical systems; site-directed immobilization of antibodies using different methods; study of proteins interaction; synthesis of p-p conjugated polymers and application in analytical systems.

Senior Researcher
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PhD Irena Dumalakienė

Senior Researcher

Education

 Higher
Employment State Research Institute for Innovative Medicine Centre, Senior Researcher
Publications 1. Mieliauskaite D, Venalis P, Dumalakiene I, Venalis A, Distler J. Relationship between serum levels of TGF-beta1 and clinical parameters in patients with rheumatoid arthritis and Sjögren’s syndrome secondary to rheumatoid arthritis. Autoimmunity, 2009 May: 42 (4), 356-8.
2. G.Vyšniauskis, I.Dumalakienė, I.Jonauskienė. Detection of antigenic variation among strains of poultry mycoplasma by immunoblot analysis. Central European Journal of Immunology, 2010, 35(4), 207-213.
3. D. Mieliauskaite, I. Dumalakiene, R. Rugiene, Z. Mackewicz. Expression of IL-17, IL-23 and receptors of IL-17, IL-23 in minor salivary glands of patients with  primary Sjögren`s syndrome. Clin Dev Immunol, 2012, Volume 2012, Article ID 187258, 8 pages.4. R. Praninskienė, I. Dumalakienė, R. Kemežys, M. Mauricas, A. Jučaitė. Diurnal melatonin patterns in children: ready to apply in clinical practice? Pediatric Neurology 2012; 46: 70-76.
5. Reda Rimavičiūtė, Irena Dumalakienė, Rita Vilienė, Rita Meškienė, Rolandas Meškys. Construction of a DNA vector system for Mycoplasma gallinarum. Romanian Biotechnological Letters, 2012, 17 (4), 7533-7539.
6. R. Praninskienė, I. Dumalakienė, R. Kemežys, M. Mauricas, A. Jučaitė. Melatonin secretion in children with epilepsy. Epilepsy & Behavior, 2012, 25, 315-322.
7. Gintaras Sudzius, Diana Mieliauskaite, Irena Butrimiene, Almantas Siaurys, Zygmunt Mackiewicz, Irena Dumalakiene. Activity of T helper cells in patients with primary Sjögren’s syndrome. In Vivo, 2013, Vol.27 (2), 263-268 (featured in June 2013 issue of Global Medical Discovery).
8. Daiva Bartkeviciene, Ingrida Pilypiene,  Grazina Drasutiene, Raminta Bausyte,  Mykolas Mauricas, Mindaugas Silkunas, Irena Dumalakiene. Leukocytosis as a prognostic marker in the development of fetal inflammatory response syndrome. Libyan J Med, 2013, 8: DOI 10.3402/ljm.v8i0.21674.
9. Gintaras Sudzius, Diana Mieliauskaite, Almantas Siaurys, Rita Viliene, Irena Butrimiene, Dainius Characiejus & Irena Dumalakiene. Could the complement component C4 or its fragment C4d be a marker of the more severe conditions in patients with primary Sjögren’s syndrome? Rheumatol Int (2014) 34:235-241. DOI 10.1007/s00296-013-2885-y.
10. Pilypienė I, Drazdienė N, Dumalakienė I, Vezbergienė N, Bartkevičienė D, Silkūnas M, Bumbulienė Z. The significance of fetal inflammatory response syndrome in early and later adaptation of premature infants. Arch Gynecol Obstet (2015) 291:67–72. DOI 10.1007/s00404-014-3386-2
11. Gintaras Sudzius, Diana Mieliauskaite, Almantas Siaurys, Rita Viliene, Irena Butrimiene, Dainius Characiejus, and Irena Dumalakiene. Distribution of Peripheral Lymphocyte Populations in Primary Sjögren’s Syndrome Patients. Journal of Immunology Research, vol. 2015, Article ID 854706, 10 pages, 2015. doi:10.1155/2015/854706
12. Daiva Bartkeviciene, Ingrida Pilypiene, Ramašauskaitė Diana, Zakarevičienė Jolita, Laužikienė Dalia, Mindaugas Silkunas, Vankevičiūtė Rasa Aurelija, Grazina Drasutiene, Vaigauskaitė Brigita, Irena Dumalakiene. Significance of C-reactive protein in predicting fetal inflammatory response syndrome. Ginekologia Polska, 2015, vol 86, iss. 12, p. 926-931.
13. Narkeviciute I., Sudzius G., Mieliauskaite D., Mackiewicz Z., Butrimiene I. Viliene R., Dumalakiene I. Are cytotoxic effector cells changes in peripheral blood of patients with Sjogren`s syndrome related to persistent virus infection: Suggestions and conundrums, Cell. Immunol., 2016, 310, 123-130. http://dx.doi.org/10.1016/j.cellimm.2016.08.013
14. Laimis Akramas, Laima Leonaviciene, Ruta Bradunaite , Audrius Vasiliauskas, Irena Dumalakiene, Danguole Zabulyte, Teresa Normantiene, Irena Jonauskiene, Dalia Vaitkiene. Antiinflammatory effect of herbal preparations on adjuvant arthritis in rats. Turk J Vet Anim Sci, 2017, 41, 748-756.
15. Zygmunt Mackiewicz, Justyna Mażul, Ieva Narkeviciute, Irena Dumalakiene, Irena Butrimienė, Rita Viliene, Indre Stankeviciene, Diana Mieliauskaite. Sjögren‘s syndrome: concerted triggering of sicca conditions. 2019, Journal of Immunology Research, vol. 2019, Article ID 2075803, 11 pages. https://doi.org/10.1155/2019/2075803
16. Ieva Narkeviciute, Diana Mieliauskaite, Zygmunt Mackiewicz, Irena Butrimiene, Rita Viliene, Irena Dumalakiene. Distribution of Myeloid-Derived Suppressor Cells in Rheumatoid Arthritis and Sjögren’s Syndrome. Arch Rheumatol 2019;34(x):1-9. doi: 10.5606/ArchRheumatol.2019.6813.
17.  Aukse Zinkeviciene,  Irena Dumalakiene, Diana Mieliauskaite, Rita Viliene, Ieva Narkeviciute, Irute Girkontaite.  sICAM-1 as an additional parameter in the discrimination of the Sjögren syndrome and non-autoimmune sicca syndrome: a pilot study. 2019. Clinical Rheumatology. https://doi.org/10.1007/s10067-019-04621-2
18.  Akramas, L., Leonavičienė, L., Bradūnaitė, R., Vaitkienė, D., Vasiliauskas, V., Dumalakienė, I., Zabulytė, D., Normantienė, T., & Jonauskienė, I. (2019). Methylsulfonylmethane alone or in combination with thiocolchicoside modulate autoimmune disease in rats with adjuvant arthritis. Journal of the Hellenic Veterinary Medical Society, 70(2), 1561-1572. doi:http://dx.doi.org/10.12681/jhvms.20862
19.  Daiva Bartkeviciene, Ingrida Pilypienė, Danielius Serapinas  Brigita Vaigauskaite,  Rasa Aurelija Vankeviciute, Agnė Bartkevičiūtė, Ieva Narkevičiūtė, Irena Dumalakiene. Umbilical blood levels of IL-6 and TNF-α as predictors of  the central nervous system damage and retinopathy in preterm infants.  2020. American Journal of Perinatology. DOI https://doi.org/10.1055/s-0040-1701508.
20.  Rūta Bradūnaitė, Laima Leonavičienė, Laimis Akramas, Miglė Leonavičiūtė-Klimantavičienė, Audrius Vasiliauskas, Irena Dumalakienė, Irena Jonauskienė, Justinas Baleišis, and Zygmunt Mackiewicz. Anti-inflammatory and antioxidant effects of turmeric extracts in rat adjuvant arthritis. 2020. Veterinarski Arhiv 90 (4), 393-402. DOI: 10.24099/vet.arhiv.0675 [IF 0.43].
21.  Joana Korabliovienė, Mykolas Mauricas, Irena Dumalakienė, Saulius Čaplinskas, Rita Vilienė, Justinas Baleišis, Gintautas Vyšniauskis, Joanna Chorostowska-Wynimko, Ginreta Magelinskienė, Pavel Korabliov, Arunas Valiulis. BCG masking phenomena might depend on the species of Mycobacterium. 2021. Acta Microbiologica et Immunologica Hungarica . DOI: 10.1556/030.2021.01324
22. Greta Balciuniene, Violeta Gulbiniene, Irena Dumalakiene, Rita Viliene, Daiva Bartkeviciene, Ingrida Pilypiene, Grazina S. Drasutiene, Diana Ramasauskaite. Prognostic markers for chorioamnionitis: IL-6, TNF-α, and MMP-8 in vaginally obtained amniotic fluid. 2021. J. Clin. Med. 10, 1136. https://doi.org/10.3390/jcm10051136
Projects Noninvasive Immunological Analysis of Amniotic Fluid in Preterm Birth
Areas of interest, directions of cooperation

Molecular and cellular immunity studies in biological models in vitro and in vivo

Researcher
×

PhD Asta Kaušaitė – Minkštimienė

Researcher
Education Higher
The topic and institution of the defended work Some aspects in development of biofuel cells and biosensors
Employment Vilnius University, Faculty of Chemistry and Geosciences, Institute of Chemistry, associated professor
State research institute Centre for Innovative Medicine, Department of Immunology, researcher
Publications 39 scientific articles in periodical academic publications with citation index available in Clarivate Analytics Web of Science database; 1 scientific article in other foreign per-reviewed scientific journals; 4 scientific articles in Lithuanian per-reviewed periodical scientific journals and educational book.
Projects From 2020 „Promotion of Post-Doctoral Fellowships“ project Nr. 09.3.3-LMT-K-712-19-0170 „Development and study of analytical system for multiple cancer biomarkers detection“, fellowship supervisor.
From 2019 Measure No. 01.2.2-LMT-K-718 „Targeted Research in Smart Specialisation Areas“ of priority axis 1 „Promotion of research, development and innovations of the Operational Programme for the European Union Funds“ Investment in 2014–2020, activity „Attracting Foreign Researchers for Research Implementation”, project „Development of a nanobiosensor: a multiplex analysis of diagnostic  biomarkers for personalization of osteoarthritis therapy“, project participant.
Areas of interest, directions of cooperation

Analytical and bioanalytical chemistry, biochemistry, bioelectrochemistry, chemistry, biomedicine, immobilization, stabilization and modification of biomolecules, π–π cojugated polymers, their synthesis, characterization and application, electrochemical and optical biosensors, biofuel cells, self-powered biosensors, nanotechnology and nanobiotechnology, nanoscience.

Junior Researcher
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Jurgita Juršėnaitė

Junior Researcher
Education Master’s Degree in biochemistry, Vilnius University
Employment Junior Researcher
Publications 1.Juršėnaitė, Jurgita; Girkontaitė, Irutė; Šiaurys, Almantas; Mauricas, Mykolas; Characiejus, Dainius. Intratumoral accumulation and clonal expansion may not be decisive for rejection of allogeneic tumors by CD8+ T-lymphocytes // Anticancer research. Athens : International Institute of Anticancer Research. ISSN 0250-7005. eISSN 1791-7530. 2018, vol. 38, no 8, p. 4481-4484. DOI: 10.21873/anticanres.12751.
2. Juršėnaitė, Jurgita; Girkontaitė, Irutė; Mauricas, Mykolas; Eidukevičius, Rimantas; Šiaurys, Almantas; Characiejus, Dainius. Bioluminescence imaging of adoptively transferred lymphocytes during allogeneic tumor rejection // Anticancer research. Athens : International Institute of Anticancer Research. ISSN 0250-7005. 2015, Vol. 35, no 12, p. 6573-6576.     
3.Characiejus, Dainius; Juršėnaitė, Jurgita. In vivo imaging of antitumor lymphocytes // Anticancer research. Kapandriti : International Institute of Anticancer Research. ISSN 0250-7005. 2014, vol. 34, no. 10, p. 5859.
4.Juršėnaitė, Jurgita; Girkontaitė, Irutė; Mauricas, Mykolas; Eidukevičius, Rimantas; Characiejus, Dainius. Expanded effector memory T-lymphocytes in DBA/2 mice do not inhibit the growth of SL2 tumours // In vivo. Athens : International Institute of Anticancer Research. ISSN 0258-851X. 2012, Vol. 26, no. 4, p. 553-558.
Areas of interest, directions of cooperation

Cancer immunology

PhD Candidate
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Arūnas Žebrauskas

PhD Candidate
Education 1999, Medical doctor degree, Vilnius University, Vilnius, Lithuania.
2001, Master of Science in Public Health, Vilnius University, Vilnius, Lithuania.
2001, Master of Public Health, Utrecht University, Utrecht, the Netherlands and Masaryk University, Brno, Czech Republic (Joint International Masterclass Program).
The topic and institution of the defended work I am currently preparing a dissertation on the topic “Advanced therapy medicinal products separation from similar innovative medicine technologies and peculiarities, differences and problems of regulation” in Centre for Innovative Medicine, Vilnius, Lithuania.
Employment 1998-2001, Medical Auditor, State Inspectorate of Medical Audit at Lithuanian Ministry of Health.
2001-2002, Medical Doctor, National Cancer Institute, Vilnius, Lithuania.
2001-2004, General Manager, Baltic Pharmacy Center JSC, Vilnius, Lithuania.
2005 – Present, Leader of Internal Medical Audit Group, Vilnius University Hospital Žalgirio Clinics, Vilnius, Lithuania.
2015-2021, Head of Project Management department, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
Publications
  1. J.Bojsen, R.Liaudanskienė, P.Morkūnienė, E.Pincevičiūtė, V.Vinickienė, A.Žebrauskas „Rekomendacijos kokybės vadybos sistemoms Lietuvos sveikatos priežiūros įstaigose“, 2000, ISBN 9986-948-46-0. („Recommendations for quality management systems in Lithuanian health care institutions“).
Projects Grant (EU SF foundation, 2018-2021): Development of Innovation and Technology Transfer Centers in the Santara Valley.
Areas of interest, directions of cooperation

Regulatory science; Advance Therapy Medicinal Products; Regulation of Medicinal Products for Human Use; Regulation of Medical Devices; Health Care Quality Management; Public Health.

PhD Candidate
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Milda Vanagaitė – Žičkienė

PhD Candidate

Education

 High
The topic and institution of the defended work Influence of intranavic macrophages on tumor cell proliferation
Employment

Doctoral student

Senior Researcher
×

(HP) PhD Audronė Eidukaitė

Senior Researcher

Education

 Faculty of Medicine of Vilnius University

The topic and institution of the defended work

 Immunocompetent cells and status of their activity in the pathogenesis of endometriosis. 2000.
Uterine mucosal immune cells and their role in the process of reproduction. 2009.
Employment CIM, Department of Immunology
Publications
  1. Paulaviciene, Ieva Jura; Liubsys, Arunas; Eidukaite, Audrone; et al. The Effect of Prolonged Freezing and Holder Pasteurization on the Macronutrient and Bioactive Protein Compositions of Human Milk. BREASTFEEDING MEDICINE 2020;15 (9): 583-588.
  2. Ieva Jura Paulaviciene, Arunas Liubsys, Alma Molyte, Audrone Eidukaite and Vytautas Usonis. Circadian changes in the composition of human milk macronutrients depending on pregnancy duration: a cross-sectional study.  International Breastfeeding Journal.   2020;15:49-57.
  3. Ilona Paulauskaite, Audrone Eidukaite and Rasa Orentaite. Fecal Calprotectin as a Biomarker Distinguishing Infectious Cause in Acute Intestinal Infections, Comparing Different Age Groups of Children. Iran J Pediatr. 2020; 30(2):e98565.
  4. Verkauskas G, Malcius D, Eidukaite A, Vilimas J, Dasevicius D, Bilius V, Hadziselimovic F. Prospective study of histological and endocrine parameters of gonadal function in boys with cryptorchidism. J Pediatr Urol. 2016;12(4):238.1-6.
  5. Stoskus M, Eidukaite A, Griskevicius L. Defining the significance of IGF2BP1. overexpression in t(12;21)(p13;q22)-positive leukemia REH cells. Leuk Res. 2016;47:16-21.
  6. Mindaugas Stoskus, Goda Vaitkeviciene, Audrone Eidukaite, Laimonas Griskevicius. ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia. Blood Cells, Molecules and Diseases 57 (2016) 30–34.
  7. Adomaitis R, Vincel B,Eidukaite A, Ostaneviciute E, Kirka R, Bilius V, Malcius D, Verkauskas G, Hadziselimovic F. Consequences of bilateral cryptorchidism in adults. 2016 Jan 14. doi: 10.1111/and.12534.
  8. Spyridis N, Syridou G, Goossens H, Versporten A, Kopsidas J, Kourlaba G, Bielicki J, Drapier N, Zaoutis T, Tsolia M, Sharland M; A. Eidukaite et. al. Variation in paediatric hospital antibiotic guidelines in Europe. Arch Dis Child. 2016 Jan;101(1):72-6.
Projects Priority 3 „Strengthening Capacities of Researchers“. VP1-3.1-ŠMM-07-K „Support to Research Activities of Scientists and Other Researcher (Global Grant)“. “Diagnosis and treatment of intertility risk in boys with cryptorchidism“. 2013-2015
Areas of interest, directions of cooperation

Molecular allergology, immune markers of pediatric diseases

Senior Researcher
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PhD Natalija German

Senior Researcher

Education

 Higher; The doctor of physical sciences, chemistry
The topic and institution of the defended work Voltammetric determination of polycyclic aromatic hydrocarbons and their derivatives
Employment From 2018 1th February till this time the employment in the Division of Immunology, State Research Institute Center for Innovative Medicine. Occupation – senior researcher.
From 2010 1th January till 2018 31th February the employment in the Division of Immunology, State Research Institute Center for Innovative Medicine. Occupation – research scientist.
From 2009 years 10th September till 2009 years 31th December the employment in the Laboratory of Immunoanalysis and Nanotechnology, Institute of Immunology of Vilnius University. Occupation – research scientist.
2007-2009 years the employment in the Laboratory of Immunoanalysis and Nanotechnology, Institute of Immunology of Vilnius University. Occupation – research scientist – probationer.
Publications From 2017 till 2021 years 7 scientific research publications, “ISI Mater List”:

  1. N. German, A. Ramanaviciene, A. Ramanavicius. Formation and electrochemical evaluation of polyaniline and polypyrrole nanocomposites based on glucose oxidase and gold-nanostructures, Polymers, 12, 3026 (2020). doi:10.3390/polym12123026, IF 3.426
  2.  N. German, A. Popov, A. Ramanaviciene, A. Ramanavicius. Formation and electrochemical characterisation of enzyme-assisted formation of polypyrrole and polyaniline nanocomposites with embedded glucose oxidase and gold nanoparticles, Journal of Electrochemical Society, 167, 165501 (2020). doi: 10.1149/1945-7111/abc9dc // https://doi.org/10.1149/1945-7111/abc9dc, IF 3.721
  3. N. German, A. Popov, A. Ramanaviciene, A. Ramanavicius, Enzymatic formation of polyaniline, polypyrrole, and polythiophene nanoparticles with embedded glucose oxidase, Nanomaterials, 9, 806 (16 pp.) (2019). doi:10.3390/nano9050806, IF 3.811
  4. N. German, A. Ramanaviciene, A. Ramanavicius, Formation of polyaniline and polypyrrole nanocomposites with embedded glucose oxidase and gold nanoparticles, Polymers, 11, 377 (2019). doi:10.3390/polym11020377, IF 3.509
  5.  N. German, A. Ramanavicius, A. Ramanaviciene, Amperometric glucose biosensor based on electrochemically deposited gold nanoparticles covered by polypyrrole, Electroanalysis, 29, 1267-1277  (2017). http://onlinelibrary.wiley.com/doi/10.1002/elan.201600680/epdf, IF 2.471 
  6.  A. Ramanavicius, N. German, A. Ramanaviciene, Evaluation of electron transfer in electrochemical system based on immobilized gold nanoparticles and glucose oxidase, Journal of The Electrochemical Society, 164, G45-G49 (2017). PROOF, DOI: 10.1149/2.0691704jes, IF 3.014
  7. N. German, A. Popov, A. Ramanaviciene, A. Ramanavicius, Evaluation of enzymatic formation of polyaniline nanoparticles, Polymer 115, 211-216 (2017). http://dx.doi.org/10.1016/j.polymer.2017.03.028, IF 3.586
Projects 1.      Student research project‘s supervisor funded by a grant (No. 09.3.3.- LMT-K-712-16-0006) from Research Council of Lithuania “The development and practical application of a glucose biological sensor with various gold derivatives.” (The duration of the project 2019-2020 years, 6 months).
2. Participation in the project funded by a grant (No. MIP-97/2010) from Research Council of Lithuania “Multi registration system developed for potential expansion of immune sensors.” (The duration of the project 2010-2012 years). The leader of project – dr. (HP) A. Ramanaviciene.
3. Participation in the project of Action D 33 “Nanoscale electrochemical and bioprocesses (corrosion) at solid-aqueous interfaces of industrial materials” (The duration of the project 2009 years).
4. Participation in the project of Action D 43 “Colloids and interface chemistry for nanotechnology” (The duration of the project 2008 years).
Areas of interest, directions of cooperation

Electrochemical chemistry, adsorptive stripping voltammetry, carbon paste electrodes, biosensors, samiconductives polymers, the transport of electrons in electrochemical systems, the analysis of enzymes, gold nanoparticles, gold nanostructures, real samples, immunosensors, cancerogenic and mutagenic substances, surface plasmon resonance, polycyclic aromatic hydrocarbons and their derivatives, graphite and glassy carbon electrode, heavies metals.

Researcher
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PhD Anton Popov

Researcher

Education

 PhD

The topic and institution of the defended work

 Investigation of colloid solutions consisting of polymeric and metallic nanoparticles, Vilnius University
Employment State Research Institute Center for Innovative Medicine, Department of Immunology, Junior researcher
Publications
  1. Brasiunas, A. Popov, A. Ramanavicius, A. Ramanaviciene, Gold nanoparticle based colorimetric sensing strategy for the determination of reducing sugars, Food Chemistry 2021, 351, 129238. DOI: 10.1016/j.foodchem.2021.129238
  2. Popov, R. Aukstakojyte, J. Gaidukevic, V. Lisyte, A. Kausaite-Minkstimiene, J. Barkauskas, A. Ramanaviciene, Reduced Graphene Oxide and Polyaniline Nanofiber Nanocomposites for the Development of an Amperometric Glucose Biosensor. Sensors 2021, 21, 948. DOI: 10.3390/s21030948
  3. Sinusaite, A. Popov, E. Raudonyte-Svirbutaviciene, J. C. Yang, A. Kareiva, A. Zarkov, Effect of Mn doping on hydrolysis of low-temperature synthesized metastable alpha-tricalcium phosphate, Ceramics International 2021, DOI: 10.1016/j.ceramint.2021.01.052
  4. Plikusiene, V. Maciulis, O. Graniel, M. Bechelany, S. Balevicius, V. Vertelis, Z. Balevicius, A. Popov, A. Ramanavicius, A. Ramanaviciene, Total internal reflection ellipsometry for kinetics-based assessment of bovine serum albumin immobilization on ZnO nanowires, Journal of Materials Chemistry C, 2021, 9, 1345-1352. DOI: 10.1039/d0tc05193D
  5. German, A. Popov, A. Ramanaviciene, A. Ramanavicius. Formation and electrochemical characterisation of enzyme-assisted formation of polypyrrole and polyaniline nanocomposites with embedded glucose oxidase and gold nanoparticles, Journal of Electrochemical Society 2020, 167 (16), 165501. DOI: 10.1149/1945-7111/abc9dc
  6. Popov, B. Brasiunas, A. Damaskaite, I. Plikusiene, A. Ramanavicius, A. Ramanaviciene, Electrodeposited gold nanostructures for the enhancement of electrochromic properties of PANI–PEDOT film deposited on transparent electrode, Polymers 2020, 12, 2778. DOI: 10.3390/polym12122778
  7. Sinusaite, A. Popov, A. Antuzevics, K. Mazeika, D. Baltrunas, J. C. Yange, J. L. Horng, S. Shi, T. Sekino, K. Ishikawa, A. Kareiva, A. Zarkov, Fe and Zn co-substituted beta-tricalcium phosphate (β-TCP): Synthesis, structural, magnetic, mechanical and biological properties, Materials Science and Engineering: C 2020, 112, 110918. DOI: 10.1016/j.msec.2020.110918
  8. Bronusiene, A. Popov, R. Ivanauskas, I. Ancutiene, Preparation and characterization of tin sulfide films with or without sodium chloride, Chemical Physics 2020, 535, 110766. DOI: 10.1016/j.chemphys.2020.110766
  9. Popov, A. Stirke, N. Bakute, B. Brasiunas, A. Ramanavicius, A. Ramanaviciene, Efficiency of granulocyte colony-stimulating factor immobilized on magnetic microparticles on proliferation of NFS-60 cells, Colloids and Surfaces A: Physicochemical and Engineering Aspects 2019, 518, 123580. DOI: 10.1016/j.colsurfa.2019.123580
  10. German, A. Popov, A. Ramanaviciene, A. Ramanavicius, Enzymatic Formation of Polyaniline, Polypyrrole, and Polythiophene Nanoparticles with Embedded Glucose Oxidase, Nanomaterials 2019, 9 (5), 806. DOI: 10.3390/nano9050806
  11. Popov, B. Brasiunas, L. Mikoliunaite, G. Bagdziunas, A. Ramanavicius, A. Ramanaviciene, Comparative study of polyaniline (PANI), poly(3,4-ethylenedioxythiophene) (PEDOT) and PANI-PEDOT films electrodeposited on transparent indium thin oxide based electrodes, Polymer 2019, 172, 133-141. DOI: 10.1016/j.polymer.2019.03.059
  12. Sinusaite, I. Grigoraviciute-Puroniene, A. Popov, K. Ishikawa, A. Kareiva, A. Zarkov, Controllable synthesis of tricalcium phosphate (TCP) polymorphs by wet precipitation: effect of washing procedure, Ceramics International 2019, 45, 12423–12428. DOI: 10.1016/j.ceramint.2019.03.174
  13. Kisieliute, A. Popov, R. Mihaela Apetrei, G. Cârâc, I. Morkvenaite-Vilkonciene, A. Ramanaviciene, A. Ramanavicius, Towards microbial biofuel cells: improvement of charge transfer by self-modification of microoganisms with conducting polymer – polypyrrole, Chemical Engineering Journal 2019, 356, 1014-1021. DOI: 10.1016/j.cej.2018.09.026
  14. Balevicius, A. Paulauskas, I. Plikusiene, L. Mikoliunaite, M. Bechelany, A. Popov, A. Ramanavicius, A. Ramanaviciene, Towards the application of Al2O3/ZnO nanolaminates in immunosensors: total internal reflection spectroscopic ellipsometry based evaluation of BSA immobilization, Journal of Materials Chemistry C 2018, 6, 8778-8783. DOI: 10.1039/C8TC03091J
  15. German, A. Popov, A. Ramanaviciene, A. Ramanavicius, Evaluation of enzymatic formation of polyaniline nanoparticles, Polymer 2017, 115, 211-216. DOI: 10.1016/j.polymer.2017.03.028
  16. Ramanaviciene, J. Voronovic, A. Popov, R. Drevinskas, A. Kausaite-Minkstimiene, A. Ramanavicius, Investigation of biocatalytic enlargement of gold nanoparticles using dynamic light scattering and atomic force microscopy, Colloids and Surfaces A: Physicochemical and Engineering Aspects 2016, 510, 183–189. DOI: 10.1016/j.colsurfa.2016.07.078
Projects From 2020  Post-Doctoral Fellowships project Nr. 09.3.3-LMT-K-712-19-0170 “Development and study of analytical system for multiple cancer biomarkers detection” received funding from European Social Fund under grant agreement with the Research Council of Lithuania (LMTLT).
Areas of interest, directions of cooperation

Immunological sensors, biological sensors, application of nanomaterials

Engineer of microbiology
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Rita Nikitenkienė

Engineer of microbiology

Education

 University Education of Lithuanian
Employment State Research Institute Center for Innovative Medicine, Engineer of microbiology
Publications Milda Naciute, Diana Mieliauskaite, Rita Rugiene, Rita Nikitenkiene, Ligita Jancoriene, Mykolas Mauricas, Zaiga Nora-Krukle, Modra Murovska, Irute Girkontaite. The frequency and significance of the parvovirus B19 infection in patients with rheumatoid arthritis. J Gen Virol. 2016 Dec;97(12):3302-3312
Projects “Establishing of the framework to track molecular epidemiology of Parvoviruses and to correlate sequence variability with different clinical manifestations”  Mutual funds Taiwan – Latvia – Lithuania. Cooperation project, Year 2012-2014. 

PhD Candidate
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Eivina Radzevičiūtė

PhD Candidate

Education

 Vytautas Magnus University. Bachelor of Biotechnology;
Vilnius University. Master of Microbiology and Biotechnology.
The topic and institution of the defended work Effects of a Recombinant Protein That Activates the Immune System in the Treatment of Cancer. UAB „Froceth“
Employment Phd student; Engineer microbiologist
Areas of interest, directions of cooperation Immunology, immunotherapy, cancer
Prof. PhD Vitalij Novickij Head of Department, Chief Researcher
PhD Mykolas Mauricas Chief Researcher
Prof. (HP) PhD  Almira Ramanavičienė Chief Researcher
(HP) PhD Audronė Eidukaitė Senior Researcher
PhD Almantas Šiaurys Senior Researcher
PhD Auksė Zinkevičienė Senior Researcher
PhD Dainius Characiejus Senior Researcher
PhD Irena Dumalakienė Senior Researcher
PhD Natalija German Senior Researcher
PhD Aušra Nemeikaitė-Čėnienė Researcher
PhD Asta Kaušaitė-Minkštimienė Researcher
PhD Grigorij Šutov Researcher
PhD  Anton Popov Researcher
PhD Ieva Narkevičiūtė Junior Researcher
Jurgita Juršėnaitė Junior Researcher
Rita Vilienė Junior Researcher
Eivina Radzevičiūtė Junior Researcher, PhD candidate
Arūnas Žebrauskas PhD candidate
Donatas Neverauskas PhD candidate
Agnė Žiniauskaitė PhD candidate
Evelina Gorbikova PhD candidate
Milda Vanagaitė-Žičkienė PhD candidate
Robertas Čėsna PhD candidate
Zenia Volockienė Senior laboratory assistant